COMPUTER-SIMULATION OF ARTERIAL FLOW WITH APPLICATIONS TO ARTERIAL AND AORTIC STENOSES

被引:395
作者
STERGIOPULOS, N
YOUNG, DF
ROGGE, TR
机构
[1] IOWA STATE UNIV SCI & TECHNOL, DEPT AEROSP ENGN, AMES, IA 50011 USA
[2] IOWA STATE UNIV SCI & TECHNOL, ENGN MECH & BIOMED ENGN PROGRAM, AMES, IA 50011 USA
关键词
D O I
10.1016/0021-9290(92)90060-E
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A computer model for simulating pressure and flow propagation in the human arterial system is developed. The model is based on the one-dimensional flow equations and includes nonlinearities arising from geometry and material properties. Fifty-five arterial segments, representing the various major arteries, are combined to form the model of the arterial system. Particular attention is paid to the development of peripheral pressure and flow pulses under normal flow conditions and under conditions of arterial and aortic stenoses. Results show that the presence of severe arterial stenoses significantly affects the nature of the distal pressure and flow pulses. Aortic stenoses also have a profound effect on central and peripheral pressure pulse formation. Comparison with the published experimental data suggests that the model is capable of simulating arterial flow under normal flow conditions as well as conditions of stenotic obstructions in a satisfactory manner.
引用
收藏
页码:1477 / 1488
页数:12
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