SYNTHESIS AND BIOLOGICAL-ACTIVITY OF C-3' ORTHO DIHYDROXYPHTHALIMIDO CEPHALOSPORINS

被引：8

作者：

BAUDART, MG ^{[1
]}

HENNEQUIN, LF ^{[1
]}

机构：

[1] ZENECA PHARMA,CTR RECH CHEMIN VRILLY,Z I POMPELLE,F-51100 REIMS,FRANCE

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 09期

关键词：

D O I：

10.7164/antibiotics.46.1458

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of C-3' ortho dihydroxyphthalimido cephalosporins 3 approximately 7 has been prepared by reaction of C-3' aminomethyl cephalosporin 41(1)) with the corresponding N-carboethoxyphthalimides 23 approximately 25, 37, 38. These new caphalosporins exhibit excellent in vitro Gram-negative activities, including Pseudomonas aeruginosa, excellent beta-lactamases stability and pharmacokinetics equivalent or better than ceftriaxone.

引用

页码：1458 / 1470

页数：13

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