INVIVO SEQUENCE REQUIREMENTS OF THE SV40 EARLY PROMOTER REGION

被引：954

作者：

BENOIST, C ^{[1
]}

CHAMBON, P ^{[1
]}

机构：

[1] FAC MED STRASBOURG, INST CHIM BIOL,INSERM,UNITE 184,CNRS, GENET MOLEC EUCARYOTES, F-67085 STRASBOURG, FRANCE

来源：

NATURE | 1981年 / 290卷 / 5804期

关键词：

D O I：

10.1038/290304a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To investigate the sequences necessary for proper initiation of transcription of SV40 early genes, several mutants with deletions in the promoter region were constructed. The adenine-thymidine-rich TATA box region is apparently involved in fixing initiation precisely within a narrow area, but is dispensable for gene expression; sequences located > 150 base pairs upstream are indispensable for gene expression.

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页码：304 / 310

页数：7

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