P53 IMMUNOSTAINING SUGGESTS THAT UTERINE CARCINOSARCOMAS ARE MONOCLONAL

被引：76

作者：

MAYALL, F

RUTTY, K

CAMPBELL, F

GODDARD, H

机构：

[1] N MANCHESTER GRP HOSP,MANCHESTER,LANCS,ENGLAND

[2] UNIV WALES HOSP,CARDIFF,S GLAM,WALES

[3] LLANDOUGH HOSP,PENARTH,S GLAM,WALES

来源：

HISTOPATHOLOGY | 1994年 / 24卷 / 03期

关键词：

UTERUS; OVARY; CARCINOSARCOMA; MIXED MULLERIAN TUMOR; CLONALITY; P53; PROTEIN;

D O I：

10.1111/j.1365-2559.1994.tb00512.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The histogenesis of carcinosarcomas has intrigued pathologists for a long time and remains unresolved. Two main theories have been put forward, one suggesting that they are monoclonal, another suggesting that they are biclonal. Our study examined p53 immunostaining in 17 uterine carcinosarcomas (mixed Mullerian tumours) and found positivity in five (30%). There was no disparity in immunostaining between the epithelial and the stromal components in any of the 17 tumours. This concordance in every tumour would be very unlikely if carcinosarcomas are biclonal; However, it would be expected if carcinosarcomas are monoclonal.

引用

页码：211 / 214

页数：4

共 16 条

[1]

EMOTOM, 1992, CANCER, V69, P1759

[2]

GEISINGER KR, 1987, CANCER-AM CANCER SOC, V59, P1781, DOI 10.1002/1097-0142(19870515)59:10<1781::AID-CNCR2820591017>3.0.CO

[3]

2-3

[4]

GORAI I, 1993, CANCER, V71, P775, DOI 10.1002/1097-0142(19930201)71:3<775::AID-CNCR2820710321>3.0.CO

[5]

2-C

[6]

HALL PA, 1993, ONCOGENE, V8, P203

[7] MUTANT P53 - THE COMMONEST GENETIC ABNORMALITY IN HUMAN CANCER [J].

HARRIS, AL .

JOURNAL OF PATHOLOGY, 1990, 162 (01) :5-6

[8] P53 - ONCOGENE OR ANTI-ONCOGENE [J].

LANE, DP ;

BENCHIMOL, S .

GENES & DEVELOPMENT, 1990, 4 (01) :1-8

[9] P53 IMMUNOSTAINING IN THE DISTINCTION BETWEEN BENIGN AND MALIGNANT MESOTHELIAL PROLIFERATIONS USING FORMALIN-FIXED PARAFFIN SECTIONS [J].

MAYALL, FG ;

GODDARD, H ;

GIBBS, AR .

JOURNAL OF PATHOLOGY, 1992, 168 (04) :377-381

[10]

MYER R, 1930, HDB SPEZIELLEN PATHO, P412

← 1 2 →