CONTINUOUS COURSE RADIATION-THERAPY AND CONCURRENT COMBINATION CHEMOTHERAPY FOR SQUAMOUS-CELL HEAD AND NECK-CANCER

被引:15
作者
ADELSTEIN, DJ
SAXTON, JP
VANKIRK, MA
WOOD, BG
ELIACHAR, I
TUCKER, HM
LAVERTU, P
机构
[1] CLEVELAND CLIN FDN, DEPT RADIAT THERAPY, CLEVELAND, OH 44195 USA
[2] CLEVELAND CLIN FDN, DEPT OTOLARYNGOL, CLEVELAND, OH 44195 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1994年 / 17卷 / 05期
关键词
CHEMOTHERAPY; RADIOTHERAPY; HEAD AND NECK CANCER;
D O I
10.1097/00000421-199410000-00001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Concurrent radiation therapy and chemotherapy is a promising approach to the treatment of squamous cell head and neck cancer. Toxicity, however, has required either scheduled breaks in radiation therapy administration or compromise in chemotherapy dose intensity. We describe the toxicity and results in 19 patients treated at diagnosis with a continuous course of radiation therapy and intensive concurrent combination chemotherapy using 5-fluorouracil and cisplatin. Toxicity among these 19 patients was significant, including mucositis, myelosuppression, and weight loss, and aggressive supportive efforts were required. No toxic deaths occurred, however. At the end of treatment, all patients had achieved complete control of their primary-site tumor. Primary-site resection was not required in any patient for tumor control, but neck dissections were performed in selected individuals with involved nodes at diagnosis. No patient recurred at the primary site and only a single patient recurred in the neck. We conclude that this chemoradiotherapy schedule is very effective, albeit toxic. Toxicity, however, can be managed with appropriate aggressive supportive measures. Conformation of these encouraging treatment results will require performance of a randomized clinical trial.
引用
收藏
页码:369 / 373
页数:5
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