TRANSCRIPTIONAL REGULATION - FLIPPING THE MYC SWITCH

被引：34

作者：

BERNARDS, R

机构：

[1] Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX Amsterdam

来源：

CURRENT BIOLOGY | 1995年 / 5卷 / 08期

关键词：

D O I：

10.1016/S0960-9822(95)00173-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When certain cells differentiate, Myc in Myc-Max heterodimers is replaced by Mad or Mxi, generating heterodimers that suppress transcription by interacting with the repressor Sin3.

引用

页码：859 / 861

页数：3

共 13 条

[1] MAD-MAX TRANSCRIPTIONAL REPRESSION IS MEDIATED BY TERNARY COMPLEX-FORMATION WITH MAMMALIAN HOMOLOGS OF YEAST REPRESSOR SIN3
AYER, DE
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EISENMAN, RN
[J]. CELL, 1995, 80 (05) : 767 - 776
[2] MAD - A HETERODIMERIC PARTNER FOR MAX THAT ANTAGONIZES MYC TRANSCRIPTIONAL ACTIVITY
AYER, DE
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EISENMAN, RN
[J]. CELL, 1993, 72 (02) : 211 - 222
[3] A SWITCH FROM MYC-MAX TO MAD-MAX HETEROCOMPLEXES ACCOMPANIES MONOCYTE/MACROPHAGE DIFFERENTIATION
AYER, DE
EISENMAN, RN
[J]. GENES & DEVELOPMENT, 1993, 7 (11) : 2110 - 2119
[4] INTERACTION OF C-MYC WITH THE PRB-RELATED PROTEIN P107 RESULTS IN INHIBITION OF C-MYC-MEDIATED TRANSACTIVATION
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ZHU, L
BERNARDS, R
[J]. EMBO JOURNAL, 1994, 13 (17) : 4080 - 4086
[5] MAX - A HELIX-LOOP-HELIX ZIPPER PROTEIN THAT FORMS A SEQUENCE-SPECIFIC DNA-BINDING COMPLEX WITH MYC
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EISENMAN, RN
[J]. SCIENCE, 1991, 251 (4998) : 1211 - 1217
[6] BINDING AND SUPPRESSION OF THE MYC TRANSCRIPTIONAL ACTIVATION DOMAIN BY P107
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BHATIA, K
MAGRATH, IT
DANG, CV
DALLAFAVERA, R
[J]. SCIENCE, 1994, 264 (5156) : 251 - 254
[7] MYC AND MAX PROTEINS POSSESS DISTINCT TRANSCRIPTIONAL ACTIVITIES
KRETZNER, L
BLACKWOOD, EM
EISENMAN, RN
[J]. NATURE, 1992, 359 (6394) : 426 - 429
[8] C-MYC REPRESSES TRANSCRIPTION IN-VIVO BY A NOVEL MECHANISM DEPENDENT ON THE INITIATOR ELEMENT AND MYC BOX-II
LI, LH
NERLOV, C
PRENDERGAST, G
MACGREGOR, D
ZIFF, EB
[J]. EMBO JOURNAL, 1994, 13 (17) : 4070 - 4079
[9] HIERARCHICAL PHOSPHORYLATION AT N-TERMINAL TRANSFORMATION-SENSITIVE SITES IN C-MYC PROTEIN IS REGULATED BY MITOGENS AND IN MITOSIS
LUTTERBACH, B
HANN, SR
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (08) : 5510 - 5522
[10] PULVERER BJ, 1994, ONCOGENE, V9, P59

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