ON MECHANISM OF ERYTHROPOIETIN-INDUCED DIFFERENTIATION .6. INDUCED ACCUMULATION OF IRON BY MARROW CELLS

被引：52

作者：

HRINDA, ME

GOLDWASS.E

机构：

[1] Department of Biochemistry, the University of Chicago, Chicago, IL

[2] the Argonne Cancer Research Hospital Operated by the U.S. Atomic Energy Commission., Chicago, IL

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 195卷 / 01期

关键词：

D O I：

10.1016/0005-2787(69)90613-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Erythropoietin induces erythrocyte development in vivo as well as some of the biochemical aspects of such development in vitro. When rat bone marrow cells are incubated in the presence of erythropoietin a system involved in the accumulation of extracellular iron in the cell interior is rapidly formed. This induced uptake of iron is inhibited by actinomycin D, puromycin, and cycloheximide, indicating that RNA synthesis and protein synthesis are required for expression of this erythropoietin effect. Part of the protein formed as a result of erythropoietin action was identified as ferritin; the remainder of the system is as yet unidentified, but is known to be neither hemoglobin nor free iron. © 1969.

引用

页码：165 / &

共 20 条

[1] IRON PARTICLES IN NORMAL ERYTHROBLASTS AND NORMAL AND PATHOLOGICAL ERYTHROCYTES [J].

BESSIS, MC ;

BRETONGORIUS, J .

JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY, 1957, 3 (03) :503-&

[2] METHOD OF ISOLATING THE BETA-1-METAL-COMBINING GLOBULIN FROM HUMAN BLOOD PLASMA [J].

BOETTCHER, EW ;

KISTLER, P ;

NITSCHMANN, H .

NATURE, 1958, 181 (4607) :490-491

[3] IN VITRO STUDIES ON EFFECT OF ERYTHROPOIETIN ON GLUCOSAMINE-1-14C INCORPORATION INTO RAT BONE MARROW CELLS [J].

DUKES, PP ;

GOLDWASSER, E ;

TAKAKU, F .

ENDOCRINOLOGY, 1964, 74 (06) :960-&

[4] ON MECHANISM OF ERYTHROPOIETIN-INDUCED DIFFERENTIATION .I. EFFECTS OF SPECIFIC INHIBITORS ON HEMOGLOBIN SYNTHESIS [J].

GALLIENL.O ;

GOLDWASS.E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 103 (02) :319-&

[5] HEMOGLOBIN SYNTHESIS IN MARROW CELL CULTURE - EFFECT OF RAT PLASMA ON RAT CELLS [J].

GALLIENLARTIGUE, O ;

GOLDWASSER, E .

SCIENCE, 1964, 145 (362) :277-&

[6]

Goldwasser E, 1966, Curr Top Dev Biol, V1, P173, DOI 10.1016/S0070-2153(08)60013-7

[7] PROGRESS IN PURIFICATION OF ERYTHROPOIETIN [J].

GOLDWASSER, E ;

KUNG, CKH .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1968, 149 (A1) :49-+

[8] CYTOCHEMICAL STUDIES OF NUCLEIC ACIDS AND PROTEINS IN ERYTHROCYTIC DEVELOPMENT [J].

GRASSO, JA ;

WOODARD, JW ;

SWIFT, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1963, 50 (01) :134-&

[9] AN INTRACELLULAR PROTEIN INTERMEDIATE FOR HEMOGLOBIN FORMATION [J].

GREENOUGH, WB ;

THOMAS, ED ;

POTERS, T .

JOURNAL OF CLINICAL INVESTIGATION, 1962, 41 (05) :1116-&

[10] ON MECHANISM OF ERYTHROPOIETIN-INDUCED DIFFERENTIATION .V. CHARACTERIZATION OF RIBONUCLEIC ACID FORMED AS A RESULT OF ERYTHROPOIETIN ACTION [J].

GROSS, M ;

GOLDWASSER, E .

BIOCHEMISTRY, 1969, 8 (05) :1795-+

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