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REGULATION OF PHOSPHODIESTERASE AND ORNITHINE DECARBOXYLASE BY CAMP IS CELL-CYCLE INDEPENDENT

被引：25
作者：
KAISER, N
BOURNE, HR
INSEL, PA
COFFINO, P
机构：
[1] UNIV CALIF SAN FRANCISCO, DEPT MED, DIV CLIN PHARMACOL, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, DEPT PHARMACOL, SAN FRANCISCO, CA 94143 USA
[3] UNIV CALIF SAN FRANCISCO, DEPT MICROBIOL & IMMUNOL, SAN FRANCISCO, CA 94143 USA
[4] UNIV CALIF SAN FRANCISCO, CARDIOVASC RES INST, SAN FRANCISCO, CA 94143 USA
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 1979年 / 101卷 / 03期
关键词：
D O I：
10.1002/jcp.1041010304
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cyclic AMP (cAMP) causes growth arrest in G1 and induction of cAMP phosphodiesterase and decrease of ornithine decarboxylase in S49 mouse lymphoma cells. Dibutyryl cAMP treatment of partially synchronized cells causes similar changes in activities of both enzymes, regardless of position in the cell cycle. This suggests that cAMP regulation of these enzymes is not mediated by growth perturbation. Copyright © 1979 Wiley‐Liss, Inc.
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页码：369 / 374
页数：6
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