EFFECT OF NICKEL(II) AND TETRAGLYCINE ON HYDROXYLATION OF THE GUANINE MOIETY IN 2'-DEOXYGUANOSINE, DNA, AND NUCLEOHISTONE BY HYDROGEN-PEROXIDE

被引:9
作者
DATTA, AK [1 ]
NORTH, SL [1 ]
KASPRZAK, KS [1 ]
机构
[1] NCI,FCRDC,COMPARAT CARCINOGENESIS LAB,BLDG 538,ROOM 205,FREDERICK,MD 21702
关键词
NICKEL; NI(II); 2'-DEOXYGUANOSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; DNA; NUCLEOHISTONE; TETRAGLYCINE;
D O I
10.1016/0048-9697(94)90398-0
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The purpose of this study was to determine whether the Ni(II)-tetraglycine complex system (NiG4) that is known to disproportionate H2O2 at pH greater-than-or-equal-to 8 can catalyze oxidation of the guanine residues in 2'-deoxyguanosine (dG), calf thymus DNA, and calf thymus nucleohistone (NH) by H2O2 at physiological pH. Incubation of dG with H2O2 in the presence of NiG4 at 37-degrees-C, produced two effects: (a) formation of 8-hydroxy-2'-deoxyguanosine (8-OH-dG) and (b) decomposition of dG to 2,6-diamino-4-hydroxy-5-formamidopyrimidine and several low molecular weight unidentified products. The magnitude of both effects depended on incubation time (1-48 h), H2O2 concentration (7.5-40 mM), NiG4 concentration (0.1 or 1 mM), and pH (6.0-8.0). The effects were not detected below pH 6 and above pH 8.0. For 0.1 mM NiG4 and 7.5 mM H2O2, production of 8-OH-dG from dG (0.75 mM) during 24 h at 37-degrees-C was significantly lower than from NH (1 mg/ml) or DNA (0.5 mg/ml), indicating possible specific effects that might be related to the strength of interaction of NiG4 with dG, NH, or DNA. The results indicate production of hydroxyl radical or other oxidizing species in the reaction of H2O2 with NiG4 at pH 7-8. Reactions like this may be relevant to the mechanisms of Ni(II)-mediated oxidative damage, observed in vitro and in vivo, which may contribute to the toxic and carcinogenic effects of this metal.
引用
收藏
页码:207 / 216
页数:10
相关论文
共 32 条
[1]   EVIDENCE FOR THE INVOLVEMENT OF HYDROXYL RADICALS IN NICKEL MEDIATED ENHANCEMENT OF LIPID-PEROXIDATION - IMPLICATIONS FOR NICKEL CARCINOGENESIS [J].
ATHAR, M ;
HASAN, SK ;
SRIVASTAVA, RC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 147 (03) :1276-1281
[2]   PRODUCTION OF SUPEROXIDE ANIONS AND HYDROGEN-PEROXIDE IN EHRLICH ASCITES TUMOR-CELL NUCLEI [J].
BARTOLI, GM ;
GALEOTTI, T ;
AZZI, A .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 497 (02) :622-626
[3]   GENETIC-EFFECTS OF THYMINE GLYCOL - SITE-SPECIFIC MUTAGENESIS AND MOLECULAR MODELING STUDIES - (IONIZING-RADIATION OXIDATIVE DAMAGE HYDROXYL RADICALS) [J].
BASU, AK ;
LOECHLER, EL ;
LEADON, SA ;
ESSIGMANN, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :7677-7681
[4]   TRIVALENT NICKEL CATALYSIS OF AUTOXIDATION OF NICKEL(II) TETRAGLYCINE [J].
BOSSU, FP ;
PANIAGO, EB ;
MARGERUM, DW ;
KIRKSEY, ST ;
KURTZ, JL .
INORGANIC CHEMISTRY, 1978, 17 (04) :1034-1042
[5]  
CALLAN WM, 1973, RES COMMUN CHEM PATH, V5, P459
[6]   TOXICITY AND CARCINOGENICITY OF NICKEL COMPOUNDS [J].
COOGAN, TP ;
LATTA, DM ;
SNOW, ET ;
COSTA, M .
CRC CRITICAL REVIEWS IN TOXICOLOGY, 1989, 19 (04) :341-384
[7]   ENHANCEMENT BY NICKEL(II) AND L-HISTIDINE OF 2'-DEOXYGUANOSINE OXIDATION WITH HYDROGEN-PEROXIDE [J].
DATTA, AK ;
MISRA, M ;
NORTH, SL ;
KASPRZAK, KS .
CARCINOGENESIS, 1992, 13 (02) :283-287
[8]   CHEMICAL DETERMINATION OF FREE RADICAL-INDUCED DAMAGE TO DNA [J].
DIZDAROGLU, M .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 10 (3-4) :225-242
[9]   DNA DAMAGE BY OXYGEN-DERIVED SPECIES - ITS MECHANISM AND MEASUREMENT IN MAMMALIAN SYSTEMS [J].
HALLIWELL, B ;
ARUOMA, OI .
FEBS LETTERS, 1991, 281 (1-2) :9-19