PHARMACOLOGY OF ORGANOPHOSPHATES

被引：42

作者：

KOELLE, GB

机构：

[1] Department of Pharmacology, Medical School, University of Pennsylvania, Philadelphia, Pennsylvania

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1994年 / 14卷 / 02期

关键词：

ORGANOPHOSPHATES; ANTICHOLINESTERASE AGENTS; ACETYLCHOLINESTERASE INHIBITORS; EPIDEMIOLOGY; DIPOLE-INDUCED DIPOLE BOND; OCULAR EFFECTS; CHEMICAL WARFARE AGENTS;

D O I：

10.1002/jat.2550140211

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The cholinergic nerve fibers, which employ acetylcholine (ACh) as a neurohumoral transmitter, and the results of their activation are listed. The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described. The limited therapeutic uses of the anticholinesterase (anti-ChE) agents are considered. The toxicological effects encountered when the anti-ChE agents are employed as insecticides or as chemical warfare (CW) agents are discussed. Certain anti-ChE agents produce also a delayed neurotoxic effect which is apparently unrelated to the inhibition of AChE.

引用

页码：105 / 109

页数：5

共 7 条

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[7] NEUROTOXICANT SENSITIVE ESTERASE - ENZYMOLOGY AND PATHOPHYSIOLOGY OF ORGANOPHOSPHORUS ESTER-INDUCED DELAYED NEUROPATHY
ZECH, R
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