THE ENDOTHELIN ET(A) RECEPTOR ANTAGONIST, BQ-123, NORMALIZES THE RESPONSE OF SHR AORTA TO CA2+ CHANNEL ACTIVATOR

被引：8

作者：

MOREL, N ^{[1
]}

GODFRAIND, T ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN,PHARMACOL LAB,B-1200 BRUSSELS,BELGIUM

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 252卷 / 02期

关键词：

CA2+ CHANNEL; ENDOTHELIN; HYPERTENSION;

D O I：

10.1016/0014-2999(94)90603-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypertension is associated with a hypersensitive response to the Ca2+ channel activator, Bay K 8644. We investigated the effect of the endothelin ET(A) receptor antagonist, BQ-123, on the contractions induced by Bay K 8644 in aorta from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats. BQ-123 (1 mu M) decreased the sensitivity to Bay K 8644 of aorta of SHR down to that of WKY. This observation is consistent with a role for endothelin in hypertension.

引用

页码：R3 / R4

页数：2

共 8 条

[1]

GEDFRAIND T, 1989, J CARDIOVASC PHAR S5, V13, pS11

[2] EFFECTS OF A CHRONIC TREATMENT BY NISOLDIPINE, A CALCIUM ANTAGONISTIC DIHYDROPYRIDINE, ON ARTERIES OF SPONTANEOUSLY HYPERTENSIVE RATS [J].

GODFRAIND, T ;

KAZDA, S ;

WIBO, M .

CIRCULATION RESEARCH, 1991, 68 (03) :674-682

[3] BIOLOGICAL PROFILES OF HIGHLY POTENT NOVEL ENDOTHELIN ANTAGONISTS SELECTIVE FOR THE ETA RECEPTOR [J].

IHARA, M ;

NOGUCHI, K ;

SAEKI, T ;

FUKURODA, T ;

TSUCHIDA, S ;

KIMURA, S ;

FUKAMI, T ;

ISHIKAWA, K ;

NISHIKIBE, M ;

YANO, M .

LIFE SCIENCES, 1992, 50 (04) :247-255

[4] EFFECT OF NITRIC-OXIDE ON MEMBRANE-POTENTIAL AND CONTRACTION OF RAT AORTA [J].

KRIPPEITDREWS, P ;

MOREL, N ;

GODFRAIND, T .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1992, 20 :S72-S75

[5] INCREASED EXPRESSION OF ENDOTHELIN-1 GENE IN BLOOD-VESSELS OF DEOXYCORTICOSTERONE ACETATE SALT HYPERTENSIVE RATS [J].

LARIVIERE, R ;

DAY, R ;

SCHIFFRIN, EL .

HYPERTENSION, 1993, 21 (06) :916-920

[6] ENDOTHELIUM-DERIVED CONTRACTING FACTORS [J].

LUSCHER, TF ;

BOULANGER, CM ;

DOHI, Y ;

YANG, ZH .

HYPERTENSION, 1992, 19 (02) :117-130

[7]

Morel N., 1993, Fundamental and Clinical Pharmacology, V7, P372

[8] ANTIHYPERTENSIVE EFFECT OF A NEWLY SYNTHESIZED ENDOTHELIN ANTAGONIST, BQ-123, IN A GENETIC HYPERTENSIVE MODEL [J].

NISHIKIBE, M ;

TSUCHIDA, S ;

OKADA, M ;

FUKURODA, T ;

SHIMAMOTO, K ;

YANO, M ;

ISHIKAWA, K ;

IKEMOTO, F .

LIFE SCIENCES, 1993, 52 (08) :717-724

← 1 →