TOPICALLY EFFECTIVE OCULAR HYPOTENSIVE ACETAZOLAMIDE AND ETHOXYZOLAMIDE FORMULATIONS IN RABBITS

被引：54

作者：

LOFTSSON, T ^{[1
]}

FRIORIKSDOTTIR, H ^{[1
]}

STEFANSSON, E ^{[1
]}

THORISDOTTIR, S ^{[1
]}

GUOMUNDSSON, O ^{[1
]}

SIGTHORSSON, T ^{[1
]}

机构：

[1] UNIV ICELAND,FAC MED,DEPT OPHTHALMOL,REYKJAVIK,ICELAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 06期

关键词：

D O I：

10.1111/j.2042-7158.1994.tb03835.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of topically active 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) eye-drop formulations containing solutions of acetazolamide, ethoxyzolamide or timolol on the intra-ocular pressure (IOP) was investigated in normotensive conscious rabbits. Both acetazolamide and ethoxyzolamide were active but their IOP-lowering effect was less than that of timolol. The IOP-lowering effects of acetazolamide and ethoxyzolamide and that of timolol appeared to be to some extent additive. Combination of acetazolamide and timolol or ethoxyzolamide and timolol in one HP-beta-CyD formulation resulted in a significant increase in the duration of activity compared with HP-beta-CyD formulations containing only acetazolamide, ethoxyzolamide or timolol. Also, it was possible to increase the IOP-lowering effect of acetazolamide by formulating the drug as a suspension in an aqueous HP-beta-CyD vehicle.

引用

页码：503 / 504

页数：2

共 7 条

[1]

FRIEDMAN Z, 1985, ARCH OPHTHALMOL-CHIC, V103, P936

[2]

LOFTSSON T, 1991, EUR J PHARM BIOPHARM, V37, P30

[3]

LOFTSSON T, 1991, PZ (Pharmazeutische Zeitung) Wissenschaft, V136, P5

[4] 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN IN TOPICAL CARBONIC-ANHYDRASE INHIBITOR FORMULATIONS [J].

LOFTSSON, T ;

FRITHRIKSDOTTIR, H ;

THORISDOTTIR, S ;

STEFANSSON, E ;

SIGURTHARDOTTIR, AM ;

GUTHMUNDSSON, O ;

SIGTHORSSON, T .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 1 (04) :175-180

[5] HYDROXYPROPYL-BETA-CYCLODEXTRIN - PREPARATION AND CHARACTERIZATION - EFFECTS ON SOLUBILITY OF DRUGS [J].

PITHA, J ;

MILECKI, J ;

FALES, H ;

PANNELL, L ;

UEKAMA, K .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 29 (01) :73-82

[6]

Szejtli J, 1988, CYCLODEXTRIN TECHNOL, P39

[7]

Tous S. S., 1992, STP PHARMA SCI, V2, P125

← 1 →