INDUCTION OF ABORTION IN THE 2ND TRIMESTER BY A COMBINATION OF MISOPROSTOL AND MIFEPRISTONE - A RANDOMIZED COMPARISON BETWEEN 2 MISOPROSTOL REGIMENS

被引：69

作者：

ELREFAEY, H ^{[1
]}

TEMPLETON, A ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT OBSTET & GYNAECOL,ABERDEEN AB9 2ZD,SCOTLAND

来源：

HUMAN REPRODUCTION | 1995年 / 10卷 / 02期

关键词：

ABORTION; MIFEPRISTONE; MISOPROSTOL; PROSTAGLANDIN; 2ND TRIMESTER ABORTION;

D O I：

10.1093/oxfordjournals.humrep.a135965

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The combination of mifepristone (RU486) and prostaglandin is effective in the induction of abortion in the second trimester. The optimal regimen is still under development, but is likely to be characterized by a short induction-to-abortion interval, low incidence of side-effects and high acceptability. We have investigated further whether misoprostol, a synthetic prostaglangin E(1) analogue, can reliably induce second trimester abortion in 70 women pre-treated with mifepristone, and whether different routes of administration affect the induction-to-abortion interval. Abortion was achieved in 97% [95% confidence interval (CI) 90-100%] of cases without resort to other prostaglandin agents. The mean induction abortion time for the studied population was 6.4 h (95% CI 5.6-7.0 h). No significant difference was found between two different routes of administration, namely vaginal versus a combination of vaginal and oral. Misoprostol has a number of advantages over other prostaglandin preparations. We recommend that, following pre-treatment with mifepristone, misoprostol is used as the prostaglandin of choice to induce abortion in the second trimester.

引用

页码：475 / 478

页数：4

共 23 条

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