4-AMINO-6-CHLORO-2-PIPERAZINOPYRIMIDINES WITH SELECTIVE AFFINITY FOR ALPHA2-ADRENOCEPTORS

被引:9
作者
GUEREMY, C [1 ]
AUDIAU, F [1 ]
RENAULT, C [1 ]
BENAVIDES, J [1 ]
UZAN, A [1 ]
LEFUR, G [1 ]
机构
[1] GRP RHONE POULENC SANTE,PHARMUKA LABS,F-92231 GENNEVILLIERS,FRANCE
关键词
D O I
10.1021/jm00158a013
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1394 / 1398
页数:5
相关论文
共 15 条
[1]   2 BINDING-SITES FOR H-3-SPIROPERIDOL ON RAT STRIATAL MEMBRANES [J].
BRILEY, M ;
LANGER, SZ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 50 (03) :283-284
[2]  
BROWN DJ, 1962, PYRIMIDINES, P55
[3]   ALPHA-ADRENORECEPTOR REAGENTS .1. SYNTHESIS OF SOME 1,4-BENZODIOXANS AS SELECTIVE PRE-SYNAPTIC ALPHA-2-ADRENORECEPTOR ANTAGONISTS AND POTENTIAL ANTI-DEPRESSANTS [J].
CHAPLEO, CB ;
MYERS, PL ;
BUTLER, RCM ;
DOXEY, JC ;
ROACH, AG ;
SMITH, CFC .
JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (06) :823-831
[4]   SELECTIVE LABELING OF ALPHA-NORADRENERGIC RECEPTORS IN RAT-BRAIN WITH [DIHYDROERGOKRYPTINE-H-3] [J].
GREENBERG, DA ;
SNYDER, SH .
LIFE SCIENCES, 1977, 20 (06) :927-931
[5]   2-AMINO-6-CHLORO-4-(N-METHYLPIPERAZINO)PYRIMIDINES, INHIBITORS OF SPIROPERIDOL BINDING [J].
GUEREMY, C ;
AUDIAU, F ;
UZAN, A ;
LEFUR, G ;
LEGER, JM ;
CARPY, A .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (12) :1459-1465
[6]   REACTION OF TERTIARY AMINES WITH HALO-S-TRIAZINES AND HALOPYRIMIDINES [J].
KOBER, E ;
RATZ, R .
JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (07) :2509-&
[7]   THE EFFECTS OF METAL-IONS ON THE BINDING OF A NEW ALPHA-2-ADRENOCEPTOR ANTAGONIST RADIOLIGAND (H-3-RX-781094 IN RAT CEREBRAL-CORTEX [J].
LANE, AC ;
HOWLETT, DR ;
WALTER, DS .
BIOCHEMICAL PHARMACOLOGY, 1983, 32 (20) :3122-3125
[8]  
LANGER SZ, 1973, FRONTIERS CATECHOLAM, P543
[9]   MEZILAMINE, A NEW DOPAMINE ANTAGONIST, BLOCKS PRESYNAPTIC BUT STIMULATES POSTSYNAPTIC ALPHA-ADRENOCEPTORS [J].
LEFUR, G ;
MIZOULE, J ;
RATAUD, J ;
UZAN, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 58 (04) :359-367
[10]   SPIPERONE - LIGAND OF CHOICE FOR NEUROLEPTIC RECEPTORS .1. KINETICS AND CHARACTERISTICS OF INVITRO BINDING [J].
LEYSEN, JE ;
GOMMEREN, W ;
LADURON, PM .
BIOCHEMICAL PHARMACOLOGY, 1978, 27 (03) :307-316