OPTICALLY-ACTIVE BENZO[C]PHENANTHRENE DIOL EPOXIDES BIND EXTENSIVELY TO ADENINE IN DNA

被引：169

作者：

DIPPLE, A ^{[1
]}

PIGOTT, MA ^{[1
]}

AGARWAL, SK ^{[1
]}

YAGI, H ^{[1
]}

SAYER, JM ^{[1
]}

JERINA, DM ^{[1
]}

机构：

[1] NIDDKD,BIOORGAN CHEM LAB,BETHESDA,MD 20892

来源：

NATURE | 1987年 / 327卷 / 6122期

关键词：

D O I：

10.1038/327535a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：535 / 536

页数：2

共 20 条

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[2] BENZO[A]PYRENE-7,8-DIHYDRODIOL-9,10-EPOXIDE IS THE MAJOR METABOLITE INVOLVED IN THE BINDING OF BENZO[A]PYRENE TO DNA IN ISOLATED VIABLE RAT HEPATOCYTES
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[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1980, 29 (01) : 117 - 127
[3] BIGGER CAH, 1983, CANCER RES, V43, P5647
[4] TUMORIGENICITY OF OPTICAL ENANTIOMERS OF DIASTEREOMERIC BENZO[A]PYRENE 7,8-DIOL-9,10-EPOXIDES IN NEWBORN MICE - EXCEPTIONAL ACTIVITY OF(+)-7-BETA, 8-ALPHA-DIHYDROXY-9-ALPHA, 10-ALPHA-EPOXY-7,8.9.10-TETRAHYDROBENZOL[A]PYRENE
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[5] SPECIFIC ACTIVATION OF THE CELLULAR HARVEY-RAS ONCOGENE IN DIMETHYLBENZANTHRACENE-INDUCED MOUSE MAMMARY-TUMORS
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[J]. MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (11) : 4104 - 4108
[6] DIPPLE A, 1983, CANCER RES, V43, P4132
[7] DIPPLE A, 1983, EXTRAHEPATIC DRUG ME, P439
[8] STRUCTURE OF OVERCROWDED AROMATIC COMPOUNDS .7. OUT-OF-PLANE DEFORMATION IN BENZO[C]PHENANTHRESE AND 1,12-DIMETHYL-BENZO[C]PHENANTHRENE
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[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1963, (APR): : 2126 - &
[9] Jerina D M, 1986, Adv Exp Med Biol, V197, P11
[10] JERINA DM, 1976, DRUG METABOLISM MICR, P13

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