ANALOGS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXY-METHYLBUTYL)GUANINE .3. MODIFICATION OF A 3'-HYDROXYMETHYL GROUP

被引：16

作者：

HARNDEN, MR ^{[1
]}

JARVEST, RL ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT,DIV RES,YEW TREE BOTTOM RD,EPSOM KT18 5XQ,SURREY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1988年 / 10期

关键词：

D O I：

10.1039/p19880002777

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：2777 / 2784

页数：8

共 13 条

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[4] ANALOGS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXYMETHYLBUTYL)GUANINE .1. SUBSTITUTIONS ON C-2' OF THE ACYCLIC N-9 SUBSTITUENT [J].

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[5] AN IMPROVED SYNTHESIS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXYMETHYLBUT-1-YL)GUANINE [J].

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[6] SYNTHESIS AND ANTIVIRAL ACTIVITY OF 9-[4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL]PURINES [J].

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BACON, TH ;

BOYD, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (09) :1636-1642

[7]

HARNDEN MR, 1985, Patent No. 141927

[8] MODE OF ACTION, TOXICITY, PHARMACOKINETICS, AND EFFICACY OF SOME NEW ANTIHERPES-VIRUS GUANOSINE ANALOGS RELATED TO BUCICLOVIR [J].

LARSSON, A ;

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (04) :598-605

[9] ANTIHERPETIC ACTIVITY AND MECHANISM OF ACTION OF 9-(4-HYDROXYBUTYL)GUANINE [J].

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[10] 9-(3,4-DIHYDROXYBUTYL)GUANINE, A NEW INHIBITOR OF HERPESVIRUS MULTIPLICATION [J].

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 23 (05) :664-670

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