PATHOPHYSIOLOGY OF POST-GASTRECTOMY HYPOGLYCAEMIA

被引:50
作者
HOLDSWORTH, CD
TURNER, D
MCINTYRE, N
机构
[1] St. Bartholomews Hospital, London
[2] Department of Medicine, Guy's Hospital Medical School, London
[3] Department of Medicine, Royal Free Hospital, London
来源
BMJ-BRITISH MEDICAL JOURNAL | 1969年 / 4卷 / 5678期
关键词
D O I
10.1136/bmj.4.5678.257
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The blood glucose and plasma insulin response to oral glucose and slow intravenous infusion of glucose was determined in seven patients who had undergone partial gastrectomy or gastroenterostomy. Similar studies were conducted in normal subjects; in these experiments oral glucose administration was replaced by infusion of glucose direct into the jejunum in order to simulate the rapid gastric emptying which occurs after gastric surgery. Peak insulin levels were much higher after oral or intrajejunal glucose, though peak blood glucose levels were higher after intravenous glucose. Despite the high insulin levels occurring with oral administration the late fall in blood glucose below fasting levels was not significantly greater after oral or intrajejunal glucose than after intravenous administration of the sugar. This does not support the concept that hyperinsulinaemia alone is responsible for reactive hypoglycaemia. © 1969, British Medical Journal Publishing Group. All rights reserved.
引用
收藏
页码:257 / +
页数:1
相关论文
共 23 条
[1]  
ALPERT S, 1967, AM J GASTROENTEROL, V47, P215
[2]  
BARNES CG, 1947, LANCET, V253, P536
[3]   SPONTANEOUS HYPOGLYCEMIA [J].
CONN, JW ;
SELTZER, HS .
AMERICAN JOURNAL OF MEDICINE, 1955, 19 (03) :460-478
[4]  
CONNRAD V, 1955, ACTA GASTROENTEROLOG, V18, P655
[5]   NEW AUTOMATED METHOD FOR MEASURING GLUCOSE BY GLUCOSE OXIDASE [J].
CRAMP, DG .
JOURNAL OF CLINICAL PATHOLOGY, 1967, 20 (06) :910-&
[6]  
DE LAET J E, 1951, Acta Gastroenterol Belg, V14, P731
[7]  
EVENSEN OK, 1942, ACTA MEDICA SCA S126, P99
[8]  
HASTINGSJAMES R, 1949, LANCET, V256, P814
[9]  
HOLDSWOR CD, 1964, CLIN SCI, V27, P371
[10]  
HOLDSWORTH CD, 1968, LANCET, V2, P700