SPECIES VARIATION IN MANGANESE INDUCED CHANGES IN BRAIN BIOGENIC-AMINES

被引：18

作者：

SHUKLA, GS

CHANDRA, SV

机构：

[1] Industrial Toxicology Research Centre, Lucknow

来源：

TOXICOLOGY LETTERS | 1979年 / 3卷 / 04期

关键词：

D O I：

10.1016/0378-4274(79)90042-0

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Manganese chloride (10 mg/kg) was administered intraperitoneally daily to guinea pig pups from the second day after birth for 30 days. A marked decrease in serum tryptophan was associated with reduced levels of brain 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) in manganese-treated animals. The significance of such changes in growing guinea pigs has been discussed since these parameters remain unaffected in rats and mice after identical exposure to manganese. © 1979.

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页码：249 / 253

页数：5

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