EFFECTS OF CHRONIC MONO-AMINE OXIDASE INHIBITOR TREATMENT ON BIOGENIC-AMINE METABOLISM IN RAT-BRAIN

被引：36

作者：

ROBINSON, DS

CAMPBELL, IC

WALKER, M

STATHAM, NJ

LOVENBERG, W

MURPHY, DL

机构：

[1] NHLBI,HYPERTENS ENDOCRINE BRANCH,BETHESDA,MD 20014

[2] NIMH,CLIN NEUROPHARMACOL BRANCH,BETHESDA,MD 20014

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 10期

关键词：

aromatic amino acid decarboxylase; biogenic amines; chronic treatments; monoamine oxidase; phenelzine; tranylcypromine; tryptophan hydroxylase; tyrosine hydroxylase;

D O I：

10.1016/0028-3908(79)90021-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of acute and chronic administration of phenelzine and tranylcypromine on rat brain monoamine metabolism have been examined. Peak increases in norepinephrine, dopamine and 5-hydroxytryptamine occurred between 1 and 7 days with monoamine oxidase inhibitor treatments followed by a gradual decline in brain monoamines towards control levels with continued chronic drug administration. There was an associated adaptive increase in tryptophan hydroxylase but no change in tyrosine hydroxylase activity with chronic phenelzine treatment. Tranylcypromine did not affect tryptophan hydroxylase or tyrosine hydroxylase activities but was associated with a significant increase in aromatic amino acid decarboxylase activity after 14 and 21 days of treatment. © 1979.

引用

页码：771 / 776

页数：6

共 24 条

[1] ALTERATIONS IN BRAIN 5-HYDROXYTRYPTAMINE METABOLISM DURING WITHDRAWAL PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM [J].