ENZYMATIC-SYNTHESIS OF BETA-D-GLUCURONIDES WITH INSITU REGENERATION OF URIDINE 5'-DIPHOSPHOGLUCURONIC ACID

被引:37
作者
GYGAX, D [1 ]
SPIES, P [1 ]
WINKLER, T [1 ]
PFAAR, U [1 ]
机构
[1] CIBA GEIGY AG,DEPT PHYS,CH-4002 BASEL,SWITZERLAND
关键词
D O I
10.1016/S0040-4020(01)87124-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
beta-D-glucuronides of 1 and 2 have been synthesized by a multi-enzyme system with in situ regeneration of uridine 5'-diphosphoglucuronic acid. Crude liver homogenate containing all enzymes involved in the multi-enzyme system was used for this stereoselective one-pot reaction.
引用
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页码:5119 / 5122
页数:4
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