DETERMINANTS OF PLASMA URIC-ACID

被引：30

作者：

GULBRANDSEN, CL

MORTON, NE

RAO, DC

RHOADS, GG

KAGAN, A

机构：

[1] UNIV HAWAII,POPULAT GENET LAB,HONOLULU,HI 96822

[2] UNIV HAWAII,DEPT MED,HONOLULU,HI 96822

[3] UNIV HAWAII,SCH PUBL HLTH,HONOLULU,HI 96822

来源：

HUMAN GENETICS | 1979年 / 50卷 / 03期

关键词：

D O I：

10.1007/BF00399397

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied. © 1979 Springer-Verlag.

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页码：307 / 312

页数：6

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