THE LACK OF INTERACTION BETWEEN TEMAFLOXACIN AND COMBINED ORAL-CONTRACEPTIVE STEROIDS

被引:13
作者
BACK, DJ
TJIA, J
MARTIN, C
MILLAR, E
MANT, T
MORRISON, P
ORME, M
机构
[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL L69 3BX,ENGLAND
[2] GUYS HOSP,GUYS DRUG RES UNIT,LONDON SE1 9RT,ENGLAND
[3] ABBOTT LABS UK LTD,LONDON,ENGLAND
关键词
D O I
10.1016/0010-7824(91)90070-V
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
In view of the considerable debate concerning the possible failure of contraception in women taking broad spectrum antibiotics, we have examined a group of 12 women aged 22-32 in a controlled study. Each woman had been on long-term therapy with oral contraceptive steroids (OCS) containing ethynylestradiol (EE2) and levonorgestrel (Ng) for at least 6 months and all were in good general health. Blood samples were taken about 11.0 hours after dosing with their OCS on days 5, 6, 7 and 8 of their contraceptive cycle, for measurement of EE2, Ng, FSH and LH by radioimmunoassay. In addition blood samples were taken on days 19, 20 and 21 of the contraceptive cycle for assay of progesterone concentrations in plasma. The study was repeated in the next cycle of use of their OCS during which they took temafloxacin, a broad spectrum quinolone antibiotic in a dose of 600 mg twice daily for 7 days starting on day 1 of the cycle. All women completed the study satisfactorily as judged by diary cards, tablet counts and plasma temafloxacin concentrations. In the early part of the study some nausea and headaches were seen due to taking temafloxacin on an empty stomach but these effects were not seen when the antibiotic was later given with food. There was no evidence of any interaction between temafloxacin and the OCS. The plasma concentration of EE2 was 61.4 +/- 21.1 pg/ml in the control cycle and 68.5 +/- 26.6 pg/ml in the temafloxacin cycle. The plasma progesterone concentration was 0.53 +/- 0.1 ng/ml in the control cycle and 0.6 +/- 0.24 ng/ml in the temafloxacin cycle (p > 0.1). No woman showed any significant rise in plasma FSH or LH concentrations during temafloxacin therapy. We conclude that there is no evidence for a systematic interaction between temafloxacin and OCS and that there should be no need to use alternative contraceptive methods in women on OCS who are treated with temafloxacin.
引用
收藏
页码:317 / 323
页数:7
相关论文
共 13 条
[1]   INVESTIGATION OF THE PHARMACOKINETICS OF ETHYNYLESTRADIOL IN WOMEN USING RADIOIMMUNOASSAY [J].
BACK, DJ ;
BRECKENRIDGE, AM ;
CRAWFORD, FE ;
MACIVER, M ;
ORME, MLE ;
ROWE, PH ;
WATTS, MJ .
CONTRACEPTION, 1979, 20 (03) :263-273
[2]   EVALUATION OF COMMITTEE ON SAFETY OF MEDICINES YELLOW CARD REPORTS ON ORAL CONTRACEPTIVE DRUG INTERACTIONS WITH ANTI-CONVULSANTS AND ANTIBIOTICS [J].
BACK, DJ ;
GRIMMER, SFM ;
ORME, MLE ;
PROUDLOVE, C ;
MANN, RD ;
BRECKENRIDGE, AM .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 25 (05) :527-532
[3]   PHARMACOKINETIC DRUG-INTERACTIONS WITH ORAL-CONTRACEPTIVES [J].
BACK, DJ ;
ORME, MLE .
CLINICAL PHARMACOKINETICS, 1990, 18 (06) :472-484
[4]   EFFECT OF ANTIBIOTICS ON ENTEROHEPATIC CIRCULATION OF ETHINYLESTRADIOL AND NORETHISTERONE IN RAT [J].
BACK, DJ ;
BRECKENRIDGE, AM ;
CHALLINER, M ;
CRAWFORD, FE ;
ORME, ML ;
ROWE, PH ;
SMITH, E .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1978, 9 (06) :527-531
[5]   THE PHARMACOKINETICS OF LEVONORGESTREL AND ETHYNYLESTRADIOL IN WOMEN - STUDIES WITH OVRAN AND OVRANETTE [J].
BACK, DJ ;
BATES, M ;
BRECKENRIDGE, AM ;
HALL, JM ;
MACIVER, M ;
ORME, MLE ;
PARK, BK ;
ROWE, PH .
CONTRACEPTION, 1981, 23 (03) :229-239
[6]   THE EFFECTS OF AMPICILLIN ON ORAL-CONTRACEPTIVE STEROIDS IN WOMEN [J].
BACK, DJ ;
BRECKENRIDGE, AM ;
MACIVER, M ;
ORME, M ;
ROWE, PH ;
STAIGER, C ;
THOMAS, E ;
TJIA, J .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 14 (01) :43-48
[7]   DO ANTICONVULSANTS REDUCE THE EFFICACY OF ORAL-CONTRACEPTIVES [J].
COULAM, CB ;
ANNEGERS, JF .
EPILEPSIA, 1979, 20 (05) :519-525
[8]  
FRIEDMAN CI, 1980, OBSTET GYNECOL, V55, P33
[9]   THE EFFECT OF CO-TRIMOXAZOLE ON ORAL-CONTRACEPTIVE STEROIDS IN WOMEN [J].
GRIMMER, SFM ;
ALLEN, WL ;
BACK, DJ ;
BRECKENRIDGE, AM ;
ORME, M ;
TJIA, J .
CONTRACEPTION, 1983, 28 (01) :53-59
[10]   SINGLE LUTEAL PHASE SERUM PROGESTERONE ASSAY AS AN INDICATOR OF OVULATION [J].
ISRAEL, R ;
STONE, SC ;
THORNEYCROFT, IH ;
MISHELL, DR ;
MOYER, DL .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1972, 112 (08) :1043-+