ANTIBODIES TO HUMAN-LEUKOCYTE ANTIGENS INDICATE SUBPOPULATIONS OF MICROGLIA IN HUMAN RETINA

被引：64

作者：

PENFOLD, PL

MADIGAN, MC

PROVIS, JM

机构：

[1] UNIV SYDNEY, DEPT OPHTHALMOL, SAVE SIGHT & EYE HLTH INST, SYDNEY, NSW 2006, AUSTRALIA

[2] UNIV SYDNEY, DEPT ANAT, SYDNEY, NSW 2006, AUSTRALIA

来源：

VISUAL NEUROSCIENCE | 1991年 / 7卷 / 04期

关键词：

HUMAN RETINA; MICROGLIA; CD ANTIGENS; SUBPOPULATIONS; RETINAL FLATMOUNTS;

D O I：

10.1017/S0952523800004879

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Monoclonal antibodies to human leucocyte antigens, including anti-CD45 and anti-CD68, have been used to describe microglia in flatmounts of normal adult human retina for the first time. Anti-CD45 (the leucocyte common antigen) intensely labeled large numbers of cells in a regular distribution across the retina; anti-CD68 and anti-macrophage antibodies labeled fewer cells with distinctive morphologies, suggesting the presence of subpopulations of microglia in the human retina expressing leucocyte antigens.

引用

页码：383 / 388

页数：6

共 46 条

[1] HEAVY-METAL INTENSIFICATION OF DAB-BASED HRP REACTION-PRODUCT [J].