ACTIVATION OF PHOSPHATIDYLINOSITOL-3 KINASE BY LIGATION OF THE INTERLEUKIN-7 RECEPTOR ON HUMAN THYMOCYTES

被引：29

作者：

DADI, HK ^{[1
]}

ROIFMAN, CM ^{[1
]}

机构：

[1] HOSP SICK CHILDREN,DIV IMMUNOL ALLERGY,555 UNIV AVE,TORONTO M5G 1X8,ONTARIO,CANADA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 92卷 / 03期

关键词：

PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL-3; PHOSPHATE; PHOSPHATIDYLINOSITOL-4; RECOMBINANT HUMAN INTERLEUKIN-7;

D O I：

10.1172/JCI116736

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Interleukin-7 (IL-7) is a glycoprotein that regulates lymphocyte precursor growth and differentiation. However, the exact mechanism whereby the IL-7 receptor (IL-7R) mediates these cell growth signals remains unknown. One of the earliest metabolic events linked to mitogenic responses in other growth factor receptor systems is the activation of phosphatidylinositol-3 kinase (PI-3 kinase). We demonstrate here that ligation of the IL-7R results in dose- and time-dependent increases in PI-3 kinase activity. These results suggest that PI-3 kinase is involved in signal transduction via the IL-7R in human thymocytes.

引用

页码：1559 / 1563

页数：5

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