ANTILEISHMANIAL ACTIVITY OF THE ETHER PHOSPHOLIPID ILMOFOSINE

被引：40

作者：

CROFT, SL ^{[1
]}

NEAL, RA ^{[1
]}

THORNTON, EA ^{[1
]}

HERRMANN, DBJ ^{[1
]}

机构：

[1] BOEHRINGER MANNHEIM GMBH,DEPT IMMUNOPHARMACOL,W-6800 MANNHEIM 31,GERMANY

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1993年 / 87卷 / 02期

关键词：

D O I：

10.1016/0035-9203(93)90499-G

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The ether phospholipid ilmofosine (BM 41.440) was active in vitro against amastigotes of Leishmania donovani and an antimony-resistant line of L. infantum in mouse peritoneal macrophages with ED50 values of 3.7 muM and 3-5 muM respectively. Ilmofosine was also active against L. donovani in BALB/C mice following oral and subcutaneous dosing, with an ED50 value of 10.5 mg/kg X 5 by the oral route.

引用

页码：217 / 219

页数：3

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