CYTOCHROME P-450(CAM) MONOOXYGENASE CAN BE REDESIGNED TO CATALYZE THE REGIOSELECTIVE AROMATIC HYDROXYLATION OF DIPHENYLMETHANE

被引：24

作者：

FOWLER, SM

ENGLAND, PA

WESTLAKE, ACG

ROUCH, DR

NICKERSON, DP

BLUNT, C

BRAYBROOK, D

WEST, S

WONG, LL

FLITSCH, SL

机构：

[1] UNIV OXFORD, INORGAN CHEM LAB, OXFORD OX1 3QR, ENGLAND

[2] DYSON PERRINS LAB, OXFORD OX1 3QY, ENGLAND

[3] PHYS CHEM LAB, OXFORD OX1 3QZ, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 24期

关键词：

D O I：

10.1039/c39940002761

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A single-site mutant (Y96A) of the monooxygenase cytochrome P-450(cam) was found to bind diphenylmethane 5 and to catalyse its regioselective aromatic hydroxylation to p-hydroxydiphenylmethane 6.

引用

页码：2761 / 2762

页数：2

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