U1-70-KD AUTOANTIBODY-POSITIVE MIXED CONNECTIVE-TISSUE DISEASE IN CHILDREN - A LONGITUDINAL CLINICAL AND SEROLOGIC ANALYSIS

被引：27

作者：

HOFFMAN, RW

CASSIDY, JT

TAKEDA, Y

SMITHJONES, EI

WANG, GS

SHARP, GC

机构：

[1] UNIV MISSOURI,MED CTR,SCH MED,DEPT INTERNAL MED,DIV IMMUNOL & RHEUMATOL,COLUMBIA,MO 65201

[2] UNIV MISSOURI,MED CTR,SCH MED,DEPT PATHOL,COLUMBIA,MO 65201

[3] UNIV MISSOURI,MED CTR,SCH MED,DEPT CHILD HLTH PEDIAT,COLUMBIA,MO 65201

来源：

ARTHRITIS AND RHEUMATISM | 1993年 / 36卷 / 11期

关键词：

D O I：

10.1002/art.1780361115

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To obtain longitudinal data on the clinical, serologic, and immunogenetic features of children with mixed connective tissue disease (MCTD). Methods. Eleven children with MCTD were followed up for a mean of 9.8 years. Enzyme-linked immunosorbent assay and immunoblotting were used to analyze sera for autoantibodies to small nuclear ribonucleoprotein polypeptides. HLA types were determined in 9 patients, by microcytotoxicity and DNA typing. Results. All 11 children had anti-U1-70-kd autoantibodies. Six of 9 were positive for HLA-DR2, 4 of 9 for HLA-DR4, and 9 of 9 for either HLA-DR2 or DR4. Outcomes were favorable with no functional impairment in 8 of the 11 children and were poor in 3. Conclusion. The frequency of HLA-DR2/DR4 is increased among children with anti-U1-70-kd autoantibody positive MCTD.

引用

页码：1599 / 1602

页数：4

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