THE CELLULAR RETINOIC ACID-BINDING PROTEIN-I IS DISPENSABLE

被引：114

作者：

GORRY, P ^{[1
]}

LUFKIN, T ^{[1
]}

DIERICH, A ^{[1
]}

ROCHETTEEGLY, C ^{[1
]}

DECIMO, D ^{[1
]}

DOLLE, P ^{[1
]}

MARK, M ^{[1
]}

DURAND, B ^{[1
]}

CHAMBON, P ^{[1
]}

机构：

[1] FAC MED STRASBOURG, INST CHIM BIOL,INSERM,CNRS, UNITE BIOL MOLEC & GEN GENET 184,GENET MOLEC, F-67085 STRASBOURG, FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 19期

关键词：

RETINOID SIGNALING PATHWAY; GENE TARGETING; CELLULAR RETINOIC ACID BINDING PROTEIN I MUTANT; VITAMIN-A;

D O I：

10.1073/pnas.91.19.9032

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cellular retinoic acid binding proteins I and II (CRABPI and CRABPII) bind retinoic acid with high affinity, exhibit distinct patterns of expression during embryonic development, and are thought to play important roles in the RA signaling pathway. We have generated a targeted mutation of the CRABPI gene using the ''hit-and-run'' strategy and shown that it prevents the production of a functional CRABPI protein. Homozygous mutant mice were normal, indicating that CRABPI does not play a crucial role in the RA signaling pathway.

引用

页码：9032 / 9036

页数：5

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