A NEW ROUTE TO 5,6-DIARYLPYRIDAZIN-3-ONES BY METALATION AND CROSS-COUPLING OF PYRIDAZINES

被引：18

作者：

TRECOURT, F

TURCK, A

PLE, N

PARIS, A

QUEGUINER, G

机构：

[1] INST RECH CHIM ORGAN FINE,CHIM ORGAN FINE & HETEROCYCL LAB,URA 1429,F-76131 MONT ST AIGNAN,FRANCE

[2] INST NATL SCI APPL,F-76131 MONT ST AIGNAN,FRANCE

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 03期

关键词：

D O I：

10.1002/jhet.5570320364

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 3,6-dichloropyridazine, a new route is described to antihypertensive 5,6-diarylpyridazin-3-ones. This pathway comprises the regioselective metalation followed by a substitution of the trimethylsilyl moeity. The introduction of iodine by another metalation allowed the cross coupling of arylboronic acids. The 6-methoxy group was then cleaved to afford the pyridazinones.

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页码：1057 / 1062

页数：6

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