PREDICTING LOCAL STRUCTURAL-CHANGES THAT RESULT FROM POINT MUTATIONS

被引：53

作者：

DEFILIPPIS, V

SANDER, C

VRIEND, G

机构：

[1] EUROPEAN MOLEC BIOL LAB,PROT DESIGN GRP,D-69117 HEIDELBERG,GERMANY

[2] CRIBI,CTR BIOTECHNOL,I-35131 PADUA,ITALY

来源：

PROTEIN ENGINEERING | 1994年 / 7卷 / 10期

关键词：

POINT MUTATIONS; PREDICTIVE RULES; PROTEIN STRUCTURE;

D O I：

10.1093/protein/7.10.1203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Point mutations are frequently used to explore the structure and/or function of proteins. The ability to predict the structural effects of point mutations would make the planning of such experiments more reliable. We have now derived a set of detailed predictive rules based on the comparison of crystal structures of point mutants and wild types in 83 cases. Despite the surprising simplicity of these rules, they describe well the conformational changes in 85% of all point mutant structures available at present.

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页码：1203 / 1208

页数：6

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