EFFECT OF LONG-TERM LITHIUM TREATMENT ON RESERPINE-INDUCED SUPER-SENSITIVITY IN DOPAMINERGIC AND SEROTONERGIC TRANSMISSION

被引：25

作者：

FRIEDMAN, E ^{[1
]}

DALLOB, A ^{[1
]}

LEVINE, G ^{[1
]}

机构：

[1] NYU,SCH MED,DEPT PHARMACOL,NEW YORK,NY 10016

来源：

LIFE SCIENCES | 1979年 / 25卷 / 14期

关键词：

D O I：

10.1016/0024-3205(79)90470-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of chronic lithium treatment on reserpine-induced supersensitivity in dopaminergic and serotonergic transmission was examined. Dopaminergic and serotonergic receptor activities were investigated employing apomorphine-induced stereotypic behavior in rats and 5-methoxy DMT-induced head twitches in mice, respectively. Reserpine increased the responsiveness to both dopaminergic and serotonergic receptor stimulations. Chronic lithium pretreatment enhanced the reserpine-elicited sensitization of both transmitter systems. © 1979.

引用

页码：1263 / 1266

页数：4

共 16 条

[1]

BUNNEY WE, 1977, NEUROREGULATORS PSYC

[2] DOPAMINE RECEPTOR-BINDING PREDICTS CLINICAL AND PHARMACOLOGICAL POTENCIES OF ANTI-SCHIZOPHRENIC DRUGS [J].