GI TRANSIT OF POTENTIAL BIOADHESIVE SYSTEMS IN THE RAT

被引：35

作者：

HARRIS, D ^{[1
]}

FELL, JT ^{[1
]}

TAYLOR, DC ^{[1
]}

LYNCH, J ^{[1
]}

SHARMA, HL ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT PHARM,OXFORD RD,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 12卷 / 01期

关键词：

bioadhesion; G.I; transit; gastric emptying; small intestinal transit times;

D O I：

10.1016/0168-3659(90)90183-T

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The oral availability of a drug may be limited by the residence time of the dose in the upper GI tract. Among the methods proposed to delay the transit of oral pharmaceutical formulations is the use of bioadhesion. The GI transit of four potential bioadhesive polymers, presented in a number of different formulations, was investigated in the rat. Formulations were dosed orally, and GI transit was assessed by killing animals at various intervals and sectioning the GI tract. Significant differences in oro-caecal transit were obtained with certain formulations, with 4% and 5% solutions of Carbopol 934 showing delays of 25% in transit to the ileo-caecal junction. © 1990.

引用

页码：55 / 65

页数：11

共 13 条

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