PRENATAL TREATMENT OF CONGENITAL ADRENAL-HYPERPLASIA - REPORT OF A NEW CASE

被引：9

作者：

LOEUILLE, GA

DAVID, M

FOREST, MG

机构：

[1] HOP CLAUDE HURIEZ,SERV GENET & MALAD HEREDITAIRES METAB ENFANT,F-59037 LILLE,FRANCE

[2] HOP DEBROUSSE,SERV PEDIAT,F-69322 LYONS 05,FRANCE

[3] HOP DEBROUSSE,INSERM,U34,F-69322 LYONS 05,FRANCE

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1990年 / 149卷 / 04期

关键词：

21-Hydroxylase deficiency; Congenital adrenal hyperplasia; Dexamethasone; Prenatal diagnosis and treatment;

D O I：

10.1007/BF02106280

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A mother at risk for 21-hydroxylase deficiency was treated with oral dexamethasone (0.5 mg 12 hourly) from early pregnancy, in an attempt to prevent in utero virilization in case of a female fetus. Fetal karyotype was 46,XX, and because of a possible intra HLA recombination, treatment was continued to term. The newborn had a modest virilization and hormonal studies confirmed the diagnosis of congenital adrenal hyperplasia (CAH). This observation and review of the literature suggest that efficient prenatal treatment of CAH requires a higher and more frequent dosage of dexamethasone. © 1990 Springer-Verlag.

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页码：237 / 240

页数：4

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