ANTICATARACTOGENIC PROPERTY OF GAMMA-GLUTAMYLCYSTEINE ETHYL-ESTER IN AN ANIMAL-MODEL OF CATARACT

被引：25

作者：

OHTSU, A

KITAHARA, S

FUJII, K

机构：

[1] Teijin Insilute for Biomedical Research, Tokyo

来源：

OPHTHALMIC RESEARCH | 1991年 / 23卷 / 01期

关键词：

GAMMA-GLUTAMYLCYSTEINE ETHYL ESTER; L-BUTHIONINE SULFOXIMINE; ANTICATARACTOGENIC AGENT; GLUTATHIONE; CATARACT MODEL; LENS CULTURE;

D O I：

10.1159/000267088

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The anticataractogenic potential of gamma-glutamylcysteine ethyl ester was investigated in model cataracts induced by L-buthionine sulfoximine. Subcutaneous injection of the ester (0.625-2.5 mmol/kg) effectively inhibited cataractogenesis in suckling mice. Treatment of mice with L-buthionine sulfoximine alone resulted in a marked reduction of the glutathione content in the eyes. This deprivation of glutathione was mitigated, to a significant degree, by coadministering gamma-glutamylcysteine ethyl ester. In an experiment with rat lens in culture, gamma-glutamylcysteine ethyl ester was found to elevate the lenticular level of glutathione. These results indicate that gamma-glutamylcysteine ethyl ester is able to permeate across biomembranes and serves as an excellent precursor for glutathione biosynthesis, thereby exerting its anticataractogenic activity.

引用

页码：51 / 58

页数：8

共 20 条

[1]

BERGMANN M, 1933, Z PHYSL CHEM, V221, P51

[2] BUTHIONINE SULFOXIMINE INHIBITION OF CYSTINE UPTAKE AND GLUTATHIONE BIOSYNTHESIS IN HUMAN-LUNG CARCINOMA-CELLS [J].