ELEVATED PLASMA-LEVELS OF PANCREASTATIN (PST) IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS (NIDDM)

被引:53
作者
FUNAKOSHI, A
TATEISHI, K
SHINOZAKI, H
MATSUMOTO, M
WAKASUGI, H
机构
[1] FUKUOKA UNIV,DEPT BIOCHEM 1,FUKUOKA 81401,JAPAN
[2] MUNICIPAL KITAKYUSHU KOKURA HOSP,KITAKYUSHU,JAPAN
[3] SANSHIN KAI HARA HOSP,FUKUOKA,JAPAN
关键词
NIDDM; Pancreastatin;
D O I
10.1016/0167-0115(90)90056-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pancreastatin (PST) is known as the peptide which inhibits first phase of glucose-stimulated insulin secretion. Fasting plasma PST levels and responses of PST after oral glucose ingestion in patients with non-insulin-dependent diabetes mellitus (NIDDM) were studied with human PST-specific radioimmunoassay. Fasting plasma PST in NIDDM patients was not different from healthy controls, although a slightly higher level of PST was observed in patients treated with sulfonylurea among NIDDM patients. No significant increase in plasma PST was observed after a glucose ingestion in healthy controls. In contrast, plasma PST levels in NIDDM patients rose significantly after glucose ingestion. These results suggest a possible pathophysiological role for PST in NIDDM. © 1990.
引用
收藏
页码:159 / 164
页数:6
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