CHOLINERGIC AGENTS - 2-OXAZOLIDINONE ANALOGS OF THE ACETYLCHOLINE-RECEPTOR MUSCARINIC AGONIST PILOCARPINE

被引：6

作者：

HOBBS, SH

JOHNSON, SJ

KESTEN, SR

PAVIA, MR

DAVIS, RE

SCHWARZ, RD

COUGHENOUR, LL

MYERS, SL

DUDLEY, DT

MOOS, WH

机构：

[1] Parke-Davis Pharmaceutical Research Division Warner-Lambert Company, Ann Arbor, MI 48106-1047

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)80787-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An oxazolidinone analogue of pilocarpine demonstrates muscarinic agonist-like properties in vitro at the acetylcholine-receptor. Replacement of the carbon alpha to the carbonyl in pilocarpine with a nitrogen represents the most active 2-oxazolidinone, comparable to pilocarpine. Further modifications abolished much of the activity, demonstrating the strict structure activity relationships intrinsic to this series.

引用

页码：147 / 150

页数：4

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