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MODULATION OF THE DOSE-DEPENDENT EFFECTS OF ATROPINE BY LOW-DOSE PYRIDOSTIGMINE - QUANTIFICATION BY SPECTRAL-ANALYSIS OF HEART-RATE FLUCTUATIONS IN HEALTHY-HUMAN BEINGS

被引：10
作者：
IZRAELI, S
ALCALAY, M
BENJAMINI, Y
WALLACHKAPON, R
TOCHNER, Z
AKSELROD, S
机构：
[1] TEL AVIV UNIV, RAYMOND & BEVERLY SACKLER FAC EXACT SCI, DEPT PHYS & ASTRON, IL-69978 TEL AVIV, ISRAEL
[2] TEL AVIV UNIV, RAYMOND & BEVERLY SACKLER FAC EXACT SCI, DEPT STAT, IL-69978 TEL AVIV, ISRAEL
[3] ISRAELI DEF FORCES, MED CORPS, TEL AVIV, ISRAEL
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 39卷 / 03期
关键词：
SPECTRAL ANALYSIS OF HEART RATE; ATROPINE; PYRIDOSTIGMINE; HUMANS; ANTICHOLINESTERASE;
D O I：
10.1016/0091-3057(91)90136-P
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The interaction between a low-dose cholinesterase inhibitor, pyridostigmine (PYR), and atropine was investigated by spectral analysis of heart rate fluctuations in eight healthy humans. Each subject was given increasing boluses of IV atropine during treatment with PYR (30 mg.3/day) or placebo. PYR attenuated the bimodal dose-dependent changes in the respiratory peak (which represents the parasympathetic control) in response to atropine. We suggest that spectral analysis can be used for quantifying the complex dose-dependent cholinergic agonist-antagonist interactions, and may help to disclose an asymptomatic low-dose intoxication with acetylcholinesterase inhibitors.
引用
收藏
页码：613 / 617
页数：5
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