SPECIES HETEROGENEITY OF HEPATIC ALPHA-1-ADRENOCEPTORS - ALPHA-1A-SUBTYPES, ALPHA-1B-SUBTYPES, AND ALPHA-1C-SUBTYPES

被引:60
作者
GARCIASAINZ, JA
ROMEROAVILA, MT
HERNANDEZ, RA
MACIASSILVA, M
OLIVARESREYES, A
GONZALEZESPINOSA, C
机构
[1] Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico D. F. 04510
关键词
D O I
10.1016/0006-291X(92)90811-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
α1-Adrenergic activation stimulated phosphorylase and phosphoinositide turnover in hepatocytes from guinea pigs, rats and rabbits. Chlorethylclonidine inhibited these effects in rat and rabbit cells but not in guinea pig hepatocytes; low concentrations of 5-methyl urapidil blocked the α1 actions in guinea pig and rabbit liver cells, but not in rat hepatocytes. Binding competition experiments also showed high affinity for 5-methyl urapidil in liver membranes from guinea pigs and rabbits and low affinity in those from rats. The data indicated that guinea pig hepatocytes express α1A-, rat hepatocytes α1B- and rabbit hepatocytes α1C-adrenoceptors. This was confirmed by Northern analysis using receptor subtype-selective probes. © 1992.
引用
收藏
页码:760 / 767
页数:8
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