SPECIES HETEROGENEITY OF HEPATIC ALPHA-1-ADRENOCEPTORS - ALPHA-1A-SUBTYPES, ALPHA-1B-SUBTYPES, AND ALPHA-1C-SUBTYPES

被引：60

作者：

GARCIASAINZ, JA

ROMEROAVILA, MT

HERNANDEZ, RA

MACIASSILVA, M

OLIVARESREYES, A

GONZALEZESPINOSA, C

机构：

[1] Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico D. F. 04510

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90811-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

α1-Adrenergic activation stimulated phosphorylase and phosphoinositide turnover in hepatocytes from guinea pigs, rats and rabbits. Chlorethylclonidine inhibited these effects in rat and rabbit cells but not in guinea pig hepatocytes; low concentrations of 5-methyl urapidil blocked the α1 actions in guinea pig and rabbit liver cells, but not in rat hepatocytes. Binding competition experiments also showed high affinity for 5-methyl urapidil in liver membranes from guinea pigs and rabbits and low affinity in those from rats. The data indicated that guinea pig hepatocytes express α1A-, rat hepatocytes α1B- and rabbit hepatocytes α1C-adrenoceptors. This was confirmed by Northern analysis using receptor subtype-selective probes. © 1992.

引用

页码：760 / 767

页数：8

共 25 条

[1] ADRENERGIC REGULATION OF GLYCOGENOLYSIS IN ISOLATED GUINEA-PIG HEPATOCYTES - EVIDENCE THAT BETA-2-RECEPTORS MEDIATE CATECHOLAMINE STIMULATION OF GLYCOGENOLYSIS [J].