REACTION OF FISCHER TYPE CHROMIUM CARBENE COMPLEXES WITH N,N-DIMETHYLFORMAMIDE DIALKYL ACETALS (DMF-DAA) - AN UNEXPECTED CARBON-CARBON BOND BREAKING

A series of pentacarbonyl(2-oxacyclopentylidene)chromium (5a-f) were reacted with NN-dimethylformamide dimethyl acetal (DMF-DMA), resulting in the pentacarbonyl(2-oxa-5-[(N,N-dimethylamino)methylidene]cyclopentylidene)chromium (6a-f) and the unexpected pentacarbonyl(2-oxa-5-(cyclopropylmethylidene)cyclopentylidene)chromium (7a-d). Open chain Fischer type carbene complexes (CO)5Cr=C(OCH3)CH2R, (1a-d) also react easily with DMF-DAA (2a-d). When R1 = H, the carbene complex (CO)5Cr=C(OCH3)CH=CHN(CH3)2 is formed in high yield; however, when R1 = alkyl, the reaction products are dialkoxy complexes (CO)5Cr=C(OCH3)OR2 (4a-d), in which the OR2 group comes from the DMF-DAA. The mechanisms of the above reactions are elucidated. The cyclopropyl ring present on compounds 7a-d arises from a contraction of the five membered ring of complexes 5a-d due to the breaking of the bond between the carbene carbon atom and the a-carbon atom. The same mechanism explains the formation of dialkoxy complexes 4a-d from complexes 1b-d. In the case of the reaction of the complex (CO)5Cr=C(OCH3)CH2CH2CH2CH3 (1d) with N,N-dimethylformamide dineopentyl acetal (2d), the intermediary formation of an enamine derivative has been demonstrated. Moreover the reaction of pentacarbonyl(2-oxa-4,4-dimethylcyclopentylidene)chromium (5g) with DMF-DMA (2a) allowed the isolation of 2,2-dimethylcyclopropanecarbaldehyde (characterized as the (2,4-dinitrophenyl)hydrazone).