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INTRAVENOUS ADMINISTRATION OF A TRANSFERRIN RECEPTOR ANTIBODY NERVE GROWTH-FACTOR CONJUGATE PREVENTS THE DEGENERATION OF CHOLINERGIC STRIATAL NEURONS IN A MODEL OF HUNTINGTON DISEASE

被引：102
作者：
KORDOWER, JH
CHARLES, V
BAYER, R
BARTUS, RT
PUTNEY, S
WALUS, LR
FRIDEN, PM
机构：
[1] RUSH PRESBYTERIAN ST LUKES MED CTR, RUSH ALZHEIMERS DIS CTR, CHICAGO, IL 60612 USA
[2] UNIV ILLINOIS, SCH MED, DEPT ANAT, CHICAGO, IL 60612 USA
[3] ALKERMES INC, CAMBRIDGE, MA 02139 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 19期
关键词：
TRANSFERRIN RECEPTOR; QUINOLINIC ACID; STRIATUM; CHOLINE ACETYLTRANSFERASE;
D O I：
10.1073/pnas.91.19.9077
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Intrastriatal injections of quinolinic acid induce a pattern of neuronal degeneration similar to that seen in Huntington disease. In the present study, nerve growth factor (NGF) crossed the blood-brain barrier in a dose dependent fashion following intravenous infusion when conjugated to an antibody directed against the transferrin receptor (OX-26). Intravenous injections of the OX-26-NGF conjugate selectively prevented the loss of striatal choline acetyltransferase-immunoreactive neurons which normally occurs following quinolinic acid administration relative to control rats receiving vehicle or a nonconjugated mixture of OX-26 and NGF. These data demonstrate that a neurotrophic factor-antibody conjugate can prevent the degeneration of central NGF responsive neurons following systemic administration.
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页码：9077 / 9080
页数：4
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