DETECTION OF P-GLYCOPROTEIN ACTIVITY ON NORMAL AND LEUKEMIC CD34+ CELLS

被引：41

作者：

DRENOU, B

FARDEL, O

AMIOT, L

FAUCHET, R

机构：

[1] Laboratoire d'Hématologie-Immunologie, Centre Hospitalier Régional et Universitaire, 35033 Rennes Cedex, Pontchaillou

来源：

LEUKEMIA RESEARCH | 1993年 / 17卷 / 12期

关键词：

ACUTE MYELOID LEUKEMIA; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; FLOW CYTOMETRY; CD34; ANTIGEN; HEMATOPOIETIC STEM CELL;

D O I：

10.1016/0145-2126(93)90159-I

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rhodamine 123 is transported by the transmembrane efflux pump P glycoprotein (Pgp). We used this fluorescent dye to study multidrug resistance (MDR) activity in normal and leukemic CD34+ cells. These immature cells had a high degree of MDR activity. Among leukemic cells, CD34+ leukemias had significantly higher MDR activity as compared to CD34-leukemias. Heterogeneous results in cell subpopulations, however, indicate that prognosis should be interpreted in the light of MDR analysis.

引用

页码：1031 / 1035

页数：5

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