MOLECULAR-CLONING OF RAT CDNA FOR CYTOSOLIC PHOSPHOLIPASE A(2) AND THE INCREASED GENE-EXPRESSION IN THE DENTATE GYRUS FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA

被引：70

作者：

OWADA, Y

TOMINAGA, T

YOSHIMOTO, T

KONDO, H

机构：

[1] TOHOKU UNIV, SCH MED, DEPT ANAT, AOBA KU, SENDAI, MIYAGI 980, JAPAN

[2] TOHOKU UNIV, SCH MED, DEPT NEUROSURG, AOBA KU, SENDAI, MIYAGI 980, JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 25卷 / 3-4期

关键词：

CDNA CLONING; ISCHEMIA; PHOSPHOLIPASE A(2); RAT BRAIN;

D O I：

10.1016/0169-328X(94)90174-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rat cytosolic phospholipase A(2) (cPLA(2)) cDNA was cloned from rat brain. The cDNA showed a high homology of 90% in the nucleotide sequence of the coding region with the human counterpart. By in situ hybridization, the gene expression for cPLA(2) was detected in the hippocampus, olfactory bulb, and cerebellar granular cells at very low level of normal rats. The expression was markedly increased in the dentate granule cells of postischemic rat brain. This alteration of the gene expression was discussed in relation to the free fatty acid-mediated neurotoxicity.

引用

页码：364 / 368

页数：5

共 18 条

[1]

ANDERSON TJ, 1979, ARCH BIOCH BIPHYS, V194, P468

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