A NEW BETA-CHAIN VARIANT, HB TYNE [BETA-5(A2)PRO-]SER]

被引：14

作者：

LANGDOWN, JV

WILLIAMSON, D

BERESFORD, CH

GIBB, I

TAYLOR, R

DEACONSMITH, R

机构：

[1] UNIV CAMBRIDGE,CTR MRC,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND

[2] ROYAL VICTORIA INFIRM,DEPT CLIN BIOCHEM,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND

[3] POOLE HOSP NATL HLTH SERV TRUST,DEPT HAEMATOL,POOLE BH15 2JB,DORSET,ENGLAND

来源：

HEMOGLOBIN | 1994年 / 18卷 / 4-5期

基金：

英国惠康基金;

关键词：

D O I：

10.3109/03630269408996199

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified a new β chain hemoglobin (Hb) variant in a 66-year-old diabetic male after an inappropriately low level of glycosylated Hb was detected by enzyme immunoassay, and confirmatory ion exchange high performance liquid chromatography (HPLC) revealed the presence of an abnormal Hb. We have subsequently identified the same Hb mutation in an apparently unrelated diabetic male, again following its detection by HPLC. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：333 / 336

页数：4

共 5 条

[1]

BASSET P, 1978, BLOOD, V51, P971

[2] SIMPLE METHOD FOR DETECTION OF UNSTABLE HEMOGLOBINS [J].