SYNTHESIS OF 5'-C-METHYL-D-ALLO-RIBONUCLEOSIDE AND L-TALO-RIBONUCLEOSIDE 3'-O-PHOSPHORAMIDITES AND THEIR INCORPORATION INTO HAMMERHEAD RIBOZYMES

被引：11

作者：

BEIGELMAN, L ^{[1
]}

KARPEISKY, A ^{[1
]}

USMAN, N ^{[1
]}

机构：

[1] RIBOZYME PHARMACEUT INC,DEPT CHEM & BIOCHEM,BOULDER,CO 80301

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012498

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5'-C-Methyl-D-allo and L-talo-ribonucleoside 3'-O-phosphoramidites were prepared from L-rhamnose in 13 and 15 steps respectively. Incorporation of L-talo residues in the hammerhead ribozyme and the resulting activity and stability of the modified ribozymes is described.

引用

页码：901 / 905

页数：5

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