TRUNCULIN-A AND TRUNCULIN-B, NORSESTERTERPENE CYCLIC PEROXIDES FROM A MARINE SPONGE, LATRUNCULIA-BREVIS

被引：70

作者：

CAPON, RJ ^{[1
]}

MACLEOD, JK ^{[1
]}

WILLIS, AC ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV, RES SCH CHEM, GPO BOX 4, CANBERRA, ACT 2601, AUSTRALIA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1987年 / 52卷 / 03期

关键词：

D O I：

10.1021/jo00379a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two norsesterterpene cyclic peroxides possessing a new carbon skeleton, trunculins A (1) and B (2), together with their methyl esters 3 and 4 have been isolated from a marine sponge, Latrunculia brevis. The esters 3 and 4 have been characterized and their relative stereostructures secured by detailed spectroscopic and X-ray analysis. Absolute stereochemistries are proposed on the basis of Horeau determinations carried out on the diol derivatives 11 and 12. The acids 1 and 2 exhibit antimicrobial activity.

引用

页码：339 / 342

页数：4

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