FIBRINOLYTIC-ACTIVITY OF VARICOSE-VEINS

被引:52
作者
WOLFE, JHN
MORLAND, M
BROWSE, NL
机构
[1] Department of Surgery, St Thomas' Hospital, London
关键词
D O I
10.1002/bjs.1800660314
中图分类号
R61 [外科手术学];
学科分类号
摘要
The plasma fibrinogen concentration, plasma fibrinolytic activity and the vein wall fibrinolytic activity of hand, groin, knee, ankle and perforating veins have been studied in 10 patients with skin changes in the lower leg secondary to venous disease (lipodermatosclerosis), in 10 patients with uncomplicated varicose veins and in 17 normal volunteers undergoing surgery. There was significantly more vein wall fibrinolytic activity in normal volunteers than in the patients with lipodermatosclerosis, not only in the ankle (P < 0.001) but also in the hand (P < 0.05). It is suggested that the reduced tissue fibrinolytic activity is a causative factor in the skin changes and ulceration of the post‐phlebitic leg, and that since the reduced activity is not confined to the leg, it may be a primary systemic defect rather than a state secondary to venous congestion. Copyright © 1979 British Journal of Surgery Society Ltd.
引用
收藏
页码:185 / 187
页数:3
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