EFFECT OF DEPOT MEDROXYPROGESTERONE ACETATE AND TESTOSTERONE OENANTHATE ON SERUM-LIPOPROTEINS IN MAN

被引：19

作者：

WALLACE, EM

WU, PCW

机构：

[1] MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, Scotland EH3 9EW

来源：

CONTRACEPTION | 1990年 / 41卷 / 01期

关键词：

D O I：

10.1016/0010-7824(90)90127-H

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Ten normal men were given three monthly intramuscular injections of 200mg of depot medroxyprogesterone acetate (DMPA) and 250mg of testosterone oenanthate (TE) as part of a male contraceptive trial. During the three months of treatment, serum high density lipoprotein cholesterol (HDL-C) and the HDL-C:LDL-C (low density lipoprotein cholesterol) ratio were significantly depressed compared to baseline. Although the long-term effect of this alteration in lipoprotein cholesterol metabolism in normolipidaemic men is currently uncertain, these results suggest that the potential cardiovascular risks of progestagen-containing regimens for male contraception will have to be seriously considered. © 1990.

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页码：63 / 71

页数：9

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