TOTAL SYNTHESIS OF 6A-CARBAPROSTAGLANDIN-I2 AND RELATED ISOMERS

被引：75

作者：

MORTON, DR

BROKAW, FC

机构：

[1] Experimental Chemistry Research, Upjohn Company, Kalamazoo

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 16期

关键词：

D O I：

10.1021/jo01330a012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of 6a-carbaprostaglandin I2 (4), an isosteric analogue of naturally occurring prostacyclin (PGI2, 1), is described. The synthetic sequence begins with the optically active, tricyclic ketone 5 and proceeds by way of the ring-expanded ketones 8 and 14. The sequence also affords the three isomeric carbocyclic analogues 36, 45, and 46, each of which exhibits lower biological activity than 4 in several test systems. © 1979, American Chemical Society. All rights reserved.

引用

页码：2880 / 2887

页数：8

共 32 条

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