INVITRO GLYCATED LOW-DENSITY-LIPOPROTEIN INTERACTION WITH HUMAN MONOCYTE-DERIVED MACROPHAGES

被引：12

作者：

CRERICHE, AG ^{[1
]}

DUMONT, S ^{[1
]}

SIFFERT, JC ^{[1
]}

STAHL, AJC ^{[1
]}

机构：

[1] UNIV LOUIS PASTEUR,FAC PHARM,IMMUNOPHARMACOL LAB,F-67401 ILLKIRCH GRAFFENS,FRANCE

来源：

RESEARCH IN IMMUNOLOGY | 1992年 / 143卷 / 01期

关键词：

LIPOPROTEIN; GLYCATION; MACROPHAGE; LDL; ACETYLATION; RECEPTOR BINDING; CELL UPTAKE; COMPETITION;

D O I：

10.1016/0923-2494(92)80075-V

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human low-density lipoprotein (LDL) was glycated in vitro (5 days, glucose 50 mmol/l), labelled with I-125, and its binding and uptake by human monocyte-derived macrophages studied. Glycation produced lower binding and lower uptake. Competition experiments using unlabelled LDL (control, glycated, and acetyl-LDL) showed that most glycated LDL was taken up by the apolipoprotein-B100: E receptor pathway. Results suggest that less of the glycated LDL may enter the cells via scavenger receptors, and very minute amount via non-saturable receptor-independent pathways.

引用

页码：17 / 23

页数：7

共 26 条

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