EFFECTS OF PROSTAGLANDINS ON CORONARY FLOW-RATE AND LEFT-VENTRICULAR WORK IN ISOLATED RAT-HEART

被引：7

作者：

DEDECKERE, EAM ^{[1
]}

机构：

[1] UNILEVER RES LAB,VLAARDINGEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 58卷 / 02期

关键词：

Coronary flow rate; Isolated rat heart; Left ventricular work; Prostaglandins;

D O I：

10.1016/0014-2999(79)90015-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In isolated rat hearts PGD2, PGE2, PGE2, PGF2α and PGI2 increased coronary flow rate at concentrations of about 23, 1.4, 0.4, 2.5 and 0.6 nmol per 1 respectively, PGD2, PGE2 and PGI2 did not effect left ventricular work (W1V). PGE1 (14 nmol/l) lowered W1V (12%) and PGF2α (9 nmol/l) increased W1V (10%). It is concluded that endogenously released PGI2 can probably affect coronary flow rate. © 1979.

引用

页码：211 / 213

页数：3

共 8 条

[1]

DEDECKERE EAM, 1979, NUTR METAB, V23, P88

[2] PROSTACYCLIN IS MAJOR PROSTAGLANDIN RELEASED FROM ISOLATED PERFUSED RABBIT AND RAT-HEART [J].